ISICEM 2023 - International Symposium on Intensive Care and Emergency Medicine

Interactive program

Speaker

Tuesday 21 March 2023

Standard presentation Gold Hall Morning (CET)

OPENING

Moderator(s): Elie Azoulay (Paris, France)
Hayley B Gershengorn (Miami, United States)

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Welcome

Fabio S Taccone (Brussels, Belgium)

Jean-Louis Vincent (Brussels, Belgium)
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Report of the Round Table conference: ICU populations: from syndromes to phenotypes

Carolyn S Calfee (San Francisco, United States)

Anthony Gordon (London, United Kingdom)
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Heterogeneous treatment effects of therapeutic-dose heparin in patients hospitalized for COVID-19

Ewan Goligher (Toronto, Canada)
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Intravenous ravulizumab in mechanically ventilated patients hospitalized with severe COVID-19

Djillali Annane (Garches, France)
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Hydrocortisone in severe community-acquired pneumonia

Nicholas Heming (Garches, France)
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Early administration of prothrombin complex concentrate in trauma patients at risk of massive transfusion (PROCOAG)

Pierre Bouzat (Grenoble, France)
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Tight glucose control in the absence of early parenteral nutrition

Jan Gunst (Leuven, Belgium)
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Low versus standard calorie and protein feeding in ventilated adults with shock (NUTRIREA-3)

Jean Reignier (Nantes, France)
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Max Harry Weil lecture: equity and equality in the ICU

Katarzyna Kotfis (Szczecin, Poland)
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Hospital violence: critical care professionals at risk

Lewis J Kaplan (Philadelphia, United States)

Standard presentation Gold Hall Morning (CET)

DONATION AFTER CARDIAC DEATH

Moderator(s): Lennie Derde (Utrecht, Netherlands)
Paul H Mayo (New York, United States)

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How to make it possible?

Marlies Ostermann (London, United Kingdom)
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How ECMO can facilitate it

Rafael Badenes (Valencia, Spain)
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How we do it

Jan Belohlavek (Prague, Czech Republic)
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How we can improve it

Jacques Creteur (Brussels, Belgium)
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Discussion

Standard presentation Gold Hall Afternoon (CET)

COVID-19: WHAT WE LEARNED

Moderator(s): Rafael Badenes (Valencia, Spain)
V Marco Ranieri (Bologna, Italy)

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Immune profiling could identify severity

Nuala Meyer (Philadelphia, United States)
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A better understanding of immunomodulation

Lieuwe Bos (Amsterdam, Netherlands)
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The different responses to convalescent plasma therapy

Manu Shankar�Hari (Edinburgh, United Kingdom)
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Discussion
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It was different in children?

Adrienne Randolph (Boston, United States)
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About the heterogeneity of myocarditis

Alain Combes (Paris, France)
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How the epidemiology of bacterial infections has been affected

Matteo Bassetti (Genoa, Italy)
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Discussion
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About antivirals

Joost Wiersinga (Amsterdam, Netherlands)
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About other ICU treatments

Anthony Gordon (London, United Kingdom)
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Anti-C5a antibody was the best

Alexander Vlaar (Amsterdam, Netherlands)
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Inhaled heparin as an option

Frank van Haren (Sidney, Australia)
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Discussion
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About stress, anxiety and burnout among the health care team

Michelle Chew (Link�ping, Sweden)
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About living guidelines

Janet Diaz (Geneva, Switzerland)
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Is there still something to learn?

Tobias Welte (Hannover, Germany)
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Discussion

Standard presentation Copper Hall Morning (CET)

SUBARACHNOID HEMORRHAGE

Moderator(s): Raimund Helbok (Linz, Austria)
David Menon (Cambridge, United Kingdom)

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Critical care management

Soojin Park (New York, United States)
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A role for other medical therapies?

Georgia Tsaousi (Thessaloniki, Greece)
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Can ROTEM help to predict cerebral ischemia?

Nicole Juffermans (Amsterdam, Netherlands)
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Delayed cerebral ischemia: still a role for induced hypertension?

Walter van den Bergh (Groningen, Netherlands)
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Discussion

Standard presentation Copper Hall Afternoon (CET)

INFECTION PREVENTION

Moderator(s): Ricard Ferrer (Barcelona, Spain)
Tim Rahmel (Bochum, Germany)

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Catheter-associated bloodstream infections

Philippe Eggimann (Lausanne, Switzerland)
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Probiotics may decrease the risk of lung infection

Evangelos Giamarellos�Bourboulis (Athens, Greece)
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Advanced airway devices to reduce risk of VAP

Paul Dark (Manchester, United Kingdom)
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Other new approaches to VAP prevention

Philippe Montravers (Paris, France)
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Discussion
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SDD - here we go again?

Jan De Waele (Ghent, Belgium)
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Why aren�t you using SDD?

Simon Finfer (Newtown, Australia)
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Indications for antibiotic prophylaxis

Pedro Povoa (Lisbon, Portugal)
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Discussion
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Break

Standard presentation Copper Hall Afternoon (CET)

TRAUMATIC BRAIN INJURY

Moderator(s): Andr� Denault (Montreal, Canada)
Soojin Park (New York, United States)

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A very heterogeneous entity!

Marek Mirski (Baltimore, United States)
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Different in pregnant patients?

Chiara Robba (Genoa, Italy)
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How has outcome improved?

David Menon (Cambridge, United Kingdom)
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Extreme therapies

Giuseppe Citerio (Monza, Italy)
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Discussion

Standard presentation Silver Hall Morning (CET)

INTRACRANIAL HYPERTENSION

Moderator(s): Geert Meyfroidt (Leuven, Belgium)
Chiara Robba (Genoa, Italy)

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Current indications for ICP monitoring

Giuseppe Citerio (Monza, Italy)
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Benefits and risks of hyperosmolar therapy

Marek Mirski (Baltimore, United States)
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Is hypertonic lactate the solution?

Mauro Oddo (Lausanne, Switzerland)
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Is hypertonic saline the solution?

Georgia Tsaousi (Thessaloniki, Greece)
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Discussion

Standard presentation Silver Hall Afternoon (CET)

NEUROMONITORING

Moderator(s): Jan Claassen (New York, United States)
Mauro Oddo (Lausanne, Switzerland)

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Pupil reactivity: the simplest method

Giuseppe Citerio (Monza, Italy)
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Biomarkers

David Menon (Cambridge, United Kingdom)
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Brain tissue oxygenation

Pierre Bouzat (Grenoble, France)
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Discussion
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Brain metabolic monitoring

Raimund Helbok (Linz, Austria)
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Multimodal brain monitoring: EEG + Doppler + NIRS

Andr� Denault (Montreal, Canada)
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How I integrate it all

Geert Meyfroidt (Leuven, Belgium)
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It�s not only a matter of thresholds

Soojin Park (New York, United States)
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Discussion

Pro-con debate Silver Hall Afternoon (CET)

CLINICAL TRIALS IN COVID:

Moderator(s): Lui Forni (Guildford, United Kingdom)

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Clinical trials in COVID:

PRO: John C Marshall (Toronto, Canada)

CON: Mervyn Singer (London, United Kingdom)

Standard presentation 100 Hall Morning (CET)

LIFE AFTER INTENSIVE CARE

Moderator(s): Carol Hodgson (Melbourne, Australia)
Peter Pickkers (Nijmegen, Netherlands)

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Quality of life after cardiac arrest

Claudio Sandroni (Rome, Italy)
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Frailty and persistent critical illness

Rinaldo Bellomo (Melbourne, Australia)
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Altered DNA methylation drives PICS

Greet Van den Berghe (Leuven, Belgium)
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What happens to the cirrhotic patient?

Thierry Gustot (Brussels, Belgium)
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Discussion

Standard presentation 100 Hall Afternoon (CET)

SHEDDING LIGHT ON ARDS

Moderator(s): Michelle N Gong (New York, United States)
B Taylor Thompson (Boston, United States)

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ARDS in immunocompromised patients is a specific entity

Alexandre Demoule (Paris, France)
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Pediatric ARDS is also different

Adrienne Randolph (Boston, United States)
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Respiratory subsets: my personal view

Jesus Villar (Las Palmas de Gran Canaria, Spain)
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Discussion
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ARDS subphenotypes: lessons from COVID-19

Lieuwe Bos (Amsterdam, Netherlands)
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Phenotypes are moving closer to clinical trials

Carolyn S Calfee (San Francisco, United States)
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Studying the lung microbiome can help

Massimo Antonelli (Rome, Italy)
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Discussion
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Break

Pro-con debate 100 Hall Afternoon (CET)

CORTICOSTEROID ADMINISTRATION IN ARDS

Moderator(s): Carolyn S Calfee (San Francisco, United States)

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Corticosteroid administration in ARDS

CON: B Taylor Thompson (Boston, United States)

PRO: Jesus Villar (Las Palmas de Gran Canaria, Spain)

Standard presentation 400 Hall Morning (CET)

CELLULAR HOMEOSTASIS

Moderator(s): Craig Jabaley (Atlanta, United States)
Edward Schenck (New York, United States)

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Mitochondrial dysfunction

Arthur van Zanten (Ede, Netherlands)
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Biogenesis

Tim Rahmel (Bochum, Germany)
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Metabolomics

Carolyn S Calfee (San Francisco, United States)
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Lipidomics

Tom van der Poll (Amsterdam, Netherlands)
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Microcirculation

Matthias Hilty (Zurich, Switzerland)
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Discussion

Standard presentation 400 Hall Afternoon (CET)

FUTURE SEPSIS THERAPIES

Moderator(s): Rinaldo Bellomo (Melbourne, Australia)
Bruno Fran�ois (Limoges, France)

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Focus on disease tolerance in sepsis

Christopher Seymour (Pittsburgh, United States)
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More immunoglobulin administration?

Tobias Welte (Hannover, Germany)
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Immune stimulation

Anthony Gordon (London, United Kingdom)
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Discussion
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Extracorporeal immune cell therapy for immune stimulation

Steffen R. Mitzner (Rostock, Germany)
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Checkpoint inhibitors

David Grimaldi (Brussels, Belgium)
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TREM-1 inhibition in septic shock

S�bastien Gibot (Nancy, France)
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Discussion
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Recombinant alkaline phosphatase for renal protection

Peter Pickkers (Nijmegen, Netherlands)
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Targeting coagulation

Julie Helms (Strasbourg, France)
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We will personalize therapies

Lennie Derde (Utrecht, Netherlands)
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Discussion

Standard presentation 400 Hall Afternoon (CET)

FLUID RESUSCITATION AND REMOVAL

Moderator(s): Marlies Ostermann (London, United Kingdom)
Jean-Louis Teboul (Le Kremlin-Bic�tre, France)

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Does the concept of liberal vs. restrictive fluid administration make sense?

Nathan Shapiro (Boston, United States)
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The limitations of fluid responsiveness tests

Sheila N Myatra (Mumbai, India)
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Look only at the peripheral perfusion

Jan Bakker (New York, United States)
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Look only at the microcirculation

Jacques Duranteau (Le Kremlin-Bic�tre, France)
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Look at the patient, not at the fluid balance

Daniel De Backer (Braine l�Alleud, Belgium)
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Discussion

Standard presentation Panoramic Room Morning (CET)

FLUID DEESCALATION

Moderator(s): Emma Bowcock (Kingswood, Australia)
Michelle Chew (Link�ping, Sweden)

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How I reduce fluid overload

Xavier Monnet (Le Kremlin-Bic�tre, France)
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Fluid deescalation: when and how?

Daniel De Backer (Braine l�Alleud, Belgium)
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It may cause harm

Can Ince (Rotterdam, Netherlands)
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Use of miniaturized systems to remove fluid

Claudio Ronco (Vicenza, Italy)
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Discussion

Standard presentation Panoramic Room Afternoon (CET)

NUTRITIONAL SUPPORT

Moderator(s): Elisabeth De Waele (Brussels, Belgium)
St�phane Gaudry (Bobigny, France)

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Enteral nutrition: my 10 recommendations

Annika Reintam Blaser (Tartu, Estonia)
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More calories?

Adam Deane (Victoria, Australia)
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More amino acids?

Nicholas Heming (Garches, France)
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More micronutrients?

Angelique de Man (Amsterdam, Netherlands)
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Discussion
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Bioimpedance may guide protein dosing

Arthur van Zanten (Ede, Netherlands)
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How the type of food can influence the acute illness

Lioudmila Karnatovskaia (Rochester, United States)
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Blood glucose targets in critically ill patients

Jan Gunst (Leuven, Belgium)
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Glucose control in diabetic patients

Adam Deane (Victoria, Australia)
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Discussion
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Break

Standard presentation Lippens Room Afternoon (CET)

HOW TO USE RESOURCES WISELY

Moderator(s): Sharon Einav (Jerusalem, Israel)
Edward Schenck (New York, United States)

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ICU admission after major surgery: is there a survival benefit?

Diamanto Aretha (Patras, Greece)
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Influence of national income on ICU structure and organization

Armand Mekontso Dessap (Cr�teil, France)
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When even the oxygen supply becomes limited

Janet Diaz (Geneva, Switzerland)
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Discussion
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The frugal intensivist: peripheral i.v. vasopressor use and no arterial line

Paul H Mayo (New York, United States)
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There are simple ways to measure blood pressure correctly

Bernd Saugel (Hamburg, Germany)
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Whatshould we do in the absence of hemodynamic monitoring devices?

Xavier Monnet (Le Kremlin-Bic�tre, France)
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Discussion

Standard presentation Lippens Room Afternoon (CET)

BIG DATABASES

Moderator(s): Vincent Liu (Oakland, United States)
Bernd Saugel (Hamburg, Germany)

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The Swiss Personalized Health Network for sepsis

Thierry Calandra (Lausanne, Switzerland)
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The French sepsis database

Djillali Annane (Garches, France)
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The Amsterdam critical care database

Nicole Juffermans (Amsterdam, Netherlands)
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Discussion
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The Michigan data driven quality improvement

Hallie Prescott (Ann Arbor, United States)
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The Australasian experience

Simon Finfer (Newtown, Australia)
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What can we do with all this data?

Edward Schenck (New York, United States)
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Discussion

Standard presentation The Arc Room Morning (CET)

NUTRITIONAL MANAGEMENT

Moderator(s): Adam Deane (Victoria, Australia)
Simon Finfer (Newtown, Australia)

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Early starvation may be desirable

Jan Gunst (Leuven, Belgium)
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What happens after ICU discharge?

Elisabeth De Waele (Brussels, Belgium)
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Should the ICU team control post-ICU nutrition?

Arthur van Zanten (Ede, Netherlands)
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How to increase awareness of all caregivers

Jean-Charles Preiser (Brussels, Belgium)
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Discussion

Tutorial The Arc Room Afternoon (CET)

PULSE OXIMETRY REVISITED

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Pulse oximetry revisited

Tomoko Fujii (Tokyo, Japan)

Tutorial The Arc Room Afternoon (CET)

PEEP TITRATION: A PRACTICAL GUIDE

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PEEP titration: a practical guide

Ewan Goligher (Toronto, Canada)

Tutorial The Arc Room Afternoon (CET)

MANAGEMENT OF CARDIOGENIC SHOCK

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Management of cardiogenic shock

Hannah Schaubroeck (Ghent, Belgium)

Tutorial The Arc Room Afternoon (CET)

VENOUS RETURN: PHYSIOLOGY AND APPLICATIONS

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Venous return: physiology and applications

Antoine Vieillard�Baron (Boulogne-Billancourt, France)

Tutorial The Arc Room Afternoon (CET)

CARDIORESPIRATORY FAILURE�IN LIVER DISEASE

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Cardiorespiratory failure�in liver disease

Julia Wendon (London, United Kingdom)

Tutorial The Arc Room Afternoon (CET)

COVID-19: A REVIEW OF PHARMACOLOGIC MANAGEMENT

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COVID-19: a review of pharmacologic management

Craig M Coopersmith (Atlanta, United States)

Round table The Arc Room Afternoon (CET)

NON-INVASIVE RESPIRATORY SUPPORT: WHAT TO CHOOSE?

Moderator(s): Laurent Brochard (Toronto, Canada)

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Non-invasive respiratory support: what to choose?

            Massimo Antonelli (Rome, Italy)

            Alexandre Demoule (Paris, France)

            Gavin Perkins (Warwick, United Kingdom)

            Lise Piquilloud (Lausanne, Switzerland)

Case discussion Box 1 Morning (CET)

PANCREATITIS

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Pancreatitis

Angelique de Man (Amsterdam, Netherlands)

Philippe Montravers (Paris, France)

Meet the experts Box 1 Morning (CET)

ECMO FOR REFRACTORY RESPIRATORY FAILURE

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ECMO for refractory respiratory failure

Daniel Brodie (Baltimore, United States)

Giacomo Grasselli (Milan, Italy)

Case discussion Box 1 Afternoon (CET)

WHICH MONITORING DO YOU NEED FOR THIS PATIENT?

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Which monitoring do you need for this patient?

Xavier Monnet (Le Kremlin-Bic�tre, France)

Meet the experts Box 1 Afternoon (CET)

VA ECMO

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VA ECMO

Federico Pappalardo (Alessandria, Italy)

Alexander Vlaar (Amsterdam, Netherlands)

Demonstration Box 1 Afternoon (CET)

CHALLENGING AIRWAYS

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Challenging airways

Audrey De Jong (Montpellier, France)

Sheila N Myatra (Mumbai, India)

Demonstration Box 1 Afternoon (CET)

PATIENT-VENTILATOR ASYNCHRONIES

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Patient-ventilator asynchronies

Leo Heunks (Rotterdam, Netherlands)

Katerina Vaporidi (Heraklion, Greece)

Meet the experts Box 1 Afternoon (CET)

PALLIATIVE CARE IN THE ICU

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Palliative care in the ICU

Jacques Creteur (Brussels, Belgium)

Victoria Metaxa (London, United Kingdom)

Demonstration Box 2 Morning (CET)

ASSESSING ARTERIAL TONE AT THE BEDSIDE

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Assessing arterial tone at the bedside

Michael R Pinsky (Pittsburgh, United States)

Jean-Louis Teboul (Le Kremlin-Bic�tre, France)

Demonstration Box 2 Morning (CET)

IDENTIFYING DYSSYNCHRONY

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Identifying dyssynchrony

Elias N Baedorf Kassis (Boston, United States)

Daniel Talmor (Boston, United States)

Clinical Challenges Box 2 Afternoon (CET)

REFRACTORY SEPTIC SHOCK

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Refractory septic shock

Alain Combes (Paris, France)

Hayley B Gershengorn (Miami, United States)

Clinical Challenges Box 2 Afternoon (CET)

HOW I OPTIMIZE POWER AT THE BEDSIDE TO AVOID VILI

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How I optimize power at the bedside to avoid VILI

Luciano Gattinoni (G�ttingen, Germany)

John J Marini (St Paul, United States)

Clinical Challenges Box 2 Afternoon (CET)

ACQUIRED DIAPHRAGM DYSFUNCTION

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Acquired diaphragm dysfunction

Alexandre Demoule (Paris, France)

Ewan Goligher (Toronto, Canada)

Clinical Challenges Box 2 Afternoon (CET)

THE FRAIL NEUROLOGICAL PATIENT

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The frail neurological patient

Raimund Helbok (Linz, Austria)

Fabio S Taccone (Brussels, Belgium)

Demonstration Box 2 Afternoon (CET)

HOW I USE ECHOCARDIOGRAPHY IN SHOCK

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How I use echocardiography in shock

Paul H Mayo (New York, United States)

Anthony McLean (Sydney, Australia)

Wednesday 22 March 2023

Standard presentation Gold Hall Morning (CET)

COVID-19: WHAT ALSO APPLIES TO BACTERIAL SEPSIS

Moderator(s): Heatherlee Bailey (Durham, United States)
Matteo Bassetti (Genoa, Italy)

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What COVID-19 taught us about sepsis

John C Marshall (Toronto, Canada)
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How different from bacterial sepsis?

Djillali Annane (Garches, France)
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Were the thrombocoagulopathic mechanisms different?

Beverley Hunt (London, United Kingdom)
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Discussion
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Were anticoagulation strategies different?

Armand Mekontso Dessap (Cr�teil, France)
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The role of platelets was interesting

Tom van der Poll (Amsterdam, Netherlands)
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The metabolic response was quite different

Elisabeth De Waele (Brussels, Belgium)
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Discussion
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Was the response of the microcirculation different?

Can Ince (Rotterdam, Netherlands)
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Was the risk of VAP particularly high?

Pedro Povoa (Lisbon, Portugal)
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We could be skeptical about corticosteroids

Daniel Talmor (Boston, United States)
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Discussion
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Anti-TREM-1 approaches are promising

Bruno Fran�ois (Limoges, France)
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Were secondary infections different?

Jan De Waele (Ghent, Belgium)
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Was the post-COVID syndrome different from PICS?

Carol Hodgson (Melbourne, Australia)
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Discussion

Standard presentation Gold Hall Afternoon (CET)

SHEDDING LIGHT ON SEPSIS

Moderator(s): Craig M Coopersmith (Atlanta, United States)
Anthony Gordon (London, United Kingdom)

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Metagenomic sequencing in the ICU

Carolyn S Calfee (San Francisco, United States)
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Is sepsis very different in children?

Adrienne Randolph (Boston, United States)
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Adaptive immune system responses during critical illness: all the same?

Manu Shankar�Hari (Edinburgh, United Kingdom)
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Subphenotyping based on organ dysfunction trajectory in sepsis

Edward Schenck (New York, United States)
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Let�s individualize corticosteroid administration

Djillali Annane (Garches, France)
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Discussion

Standard presentation Gold Hall Afternoon (CET)

PERSONALIZING THE CHOICE OF IV FLUID

Moderator(s): Ashish K Khanna (Winston-Salem, United States)
Nathan Shapiro (Boston, United States)

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Saline solutions are not bad: hyperchloremia is

Jean-Louis Vincent (Brussels, Belgium)
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Chloride is a neglected electrolyte

Luciano Gattinoni (G�ttingen, Germany)
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What�s in a bag of fluid? Tailoring the fluid to the patient

Mervyn Singer (London, United Kingdom)
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When to give bicarbonate in metabolic acidosis

Tomoko Fujii (Tokyo, Japan)
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Discussion
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Appropriate choices in sepsis

Ricard Ferrer (Barcelona, Spain)
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Why not plasma in sepsis?

Christopher Seymour (Pittsburgh, United States)
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Appropriate choices in neurological disease

Marek Mirski (Baltimore, United States)
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Appropriate choices in liver disease

Julia Wendon (London, United Kingdom)
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Discussion

Standard presentation Copper Hall Morning (CET)

HEMODYNAMIC MANAGEMENT OF THE NEUROLOGICAL PATIENT

Moderator(s): David Menon (Cambridge, United Kingdom)
Chiara Robba (Genoa, Italy)

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Ultrasound to study cerebral hemodynamics

Aarti Sarwal (Winston Salem, United States)
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Induced hypertension when needed

Fabio S Taccone (Brussels, Belgium)
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Don�t forget cardiac output!

Geert Meyfroidt (Leuven, Belgium)
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Using cardiac signals can also help

Soojin Park (New York, United States)
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Discussion

Standard presentation Copper Hall Morning (CET)

ARE OUR SYNDROMES STILL USEFUL?

Moderator(s): Lieuwe Bos (Amsterdam, Netherlands)
Manu Shankar�Hari (Edinburgh, United Kingdom)

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Is it time to abandon consensus definitions of ARDS and sepsis?

Gordon Rubenfeld (Toronto, Canada)
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If a better ARDS definition is the answer, what is the question?

V Marco Ranieri (Bologna, Italy)
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We need to expand the ARDS criteria

Oriol Roca (Sabadell, Spain)
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Sepsis subtypes

Christopher Seymour (Pittsburgh, United States)
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Discussion
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Bridging the gap for precision medicine

B Taylor Thompson (Boston, United States)
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Finding the treatable traits in ARDS and sepsis

Nuala Meyer (Philadelphia, United States)
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Let us (re)define critical illness

John C Marshall (Toronto, Canada)
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Let us better define clinical trajectories

Michelle N Gong (New York, United States)
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Discussion

Standard presentation Copper Hall Afternoon (CET)

CLINICAL TRIALS

Moderator(s): Jan Bakker (New York, United States)
Hallie Prescott (Ann Arbor, United States)

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Many practices are not based on a sound evidence base

Mervyn Singer (London, United Kingdom)
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Problems of randomized controlled trials in ARDS

Jesus Villar (Las Palmas de Gran Canaria, Spain)
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Problems with mortality as an endpoint

Michelle N Gong (New York, United States)
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Novel trial designs should include phenotypes

Christopher Seymour (Pittsburgh, United States)
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Discussion
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ICU trials should be Bayesian

Ewan Goligher (Toronto, Canada)
-

Adaptive platform trials for all

Carolyn S Calfee (San Francisco, United States)
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We could consider basket trials

B Taylor Thompson (Boston, United States)
-

Discussion
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Global collaboration is the future

John C Marshall (Toronto, Canada)
-

Using observational cohort studies to complement clinical trials

Nuala Meyer (Philadelphia, United States)
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Redesigning ICU research: more data science, fewer interventional trials

Mauro Oddo (Lausanne, Switzerland)
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Discussion

Pro-con debate Copper Hall Afternoon (CET)

ARDS: TIME TO ABANDON?

Moderator(s): Susanna Price (London, United Kingdom)

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ARDS: time to abandon?

PRO: Luciano Gattinoni (G�ttingen, Germany)

CON: Michelle N Gong (New York, United States)

Standard presentation Silver Hall Morning (CET)

VV ECMO: WHAT WE�VE LEARNED RECENTLY

Moderator(s): Laurent Brochard (Toronto, Canada)
Luciano Gattinoni (G�ttingen, Germany)

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Obesity is not a contraindication

Daniel Brodie (Baltimore, United States)
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Age limits revisited

V Marco Ranieri (Bologna, Italy)
-

Consider RV function as well

Antoine Vieillard�Baron (Boulogne-Billancourt, France)
-

Discussion
-

How we used ECMO for severe COVID-19

Alain Combes (Paris, France)
-

There was an interesting evolution in the use of ECMO during COVID-19

Daniel Brodie (Baltimore, United States)
-

How ECMO changed outcome during COVID-19

Luigi Camporota (London, United Kingdom)
-

ECMO: let�s challenge our current practices

Carol Hodgson (Melbourne, Australia)
-

Discussion
-

Break

Pro-con debate Silver Hall Morning (CET)

WE SHOULD ABANDON CVP MONITORING

Moderator(s): Hannah Schaubroeck (Ghent, Belgium)

-

We should abandon CVP monitoring

PRO: Paul H Mayo (New York, United States)

CON: Jean-Louis Teboul (Le Kremlin-Bic�tre, France)

Pro-con debate Silver Hall Morning (CET)

WE SHOULD ABANDON PRAGMATIC TRIALS

Moderator(s): Nathan Shapiro (Boston, United States)

-

We should abandon pragmatic trials

CON: Rinaldo Bellomo (Melbourne, Australia)

PRO: Jean-Louis Vincent (Brussels, Belgium)

Standard presentation Silver Hall Afternoon (CET)

DIFFICULT INFECTIONS

Moderator(s): Philippe Eggimann (Lausanne, Switzerland)
Tobias Welte (Hannover, Germany)

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First distinguish bacterial from viral infection

Pierre Hausfater (Paris, France)
-

S. aureus infections in the ICU

Sebastian Weis (Jena, Germany)
-

Klebsiella is the new threat

Matteo Bassetti (Genoa, Italy)
-

Risk stratification of multidrug resistant bacteria

Philippe Montravers (Paris, France)
-

What is the real threat from antibiotic resistance?

Liesbet De Bus (Ghent, Belgium)
-

Discussion
-

Any place for phage therapy?

Maya Hites (Brussels, Belgium)
-

How to work closely with the Infectious Disease specialist

Sebastian Weis (Jena, Germany)
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CMV in immunocompetent ICU patients: prevent, treat, or ignore

Gordon Rubenfeld (Toronto, Canada)
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Novel antifungal agents

Thierry Calandra (Lausanne, Switzerland)
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Candida resistance and antifungal stewardship

Jos�-Artur Paiva (Porto, Portugal)
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Discussion

Standard presentation 100 Hall Morning (CET)

VITAMINS

Moderator(s): Nicholas Heming (Garches, France)
Arthur van Zanten (Ede, Netherlands)

-

Vitamins and trace-elements: invisible but vital!

Elisabeth De Waele (Brussels, Belgium)
-

The cardiovascular effects of vitamin C

Angelique de Man (Amsterdam, Netherlands)
-

Mega-dose vitamin C?

Rinaldo Bellomo (Melbourne, Australia)
-

Discussion
-

Vitamin B in hypophosphatemia?

Adam Deane (Victoria, Australia)
-

Vitamin B3 for renal protection?

St�phane Gaudry (Bobigny, France)
-

When to give vitamin D?

Jean-Charles Preiser (Brussels, Belgium)
-

Vitamin D in renal failure?

Marlies Ostermann (London, United Kingdom)
-

Discussion
-

Break

Pro-con debate 100 Hall Morning (CET)

HYPOPHOSPHATEMIA SHOULD BE CORRECTED

Moderator(s): Adam Deane (Victoria, Australia)

-

Hypophosphatemia should be corrected

PRO: Jean-Charles Preiser (Brussels, Belgium)

CON: Mervyn Singer (London, United Kingdom)

Pro-con debate 100 Hall Morning (CET)

WE SHOULD MONITOR THE MICROCIRCULATION IN THE PERIOPERATIVE PERIOD

Moderator(s): Angelique de Man (Amsterdam, Netherlands)

-

We should monitor the microcirculation in the perioperative period

PRO: Jacques Duranteau (Le Kremlin-Bic�tre, France)

CON: Bernd Saugel (Hamburg, Germany)

Standard presentation 100 Hall Afternoon (CET)

THE IMMUNE RESPONSE

Moderator(s): Massimo Antonelli (Rome, Italy)
Axel Nierhaus (Hamburg, Germany)

-

The danger within our body

Evangelos Giamarellos�Bourboulis (Athens, Greece)
-

Necroinflammatory cell death in sepsis

Edward Schenck (New York, United States)
-

Endotoxin has a hormone-like effect

John C Marshall (Toronto, Canada)
-

Discussion
-

Host response aberrations in ICU-acquired pneumonia

Tom van der Poll (Amsterdam, Netherlands)
-

Myeloid-derived suppressor cells as mediators of immunosuppression

Thierry Calandra (Lausanne, Switzerland)
-

The role of mitochondria in the immune response

Anthony McLean (Sydney, Australia)
-

Discussion
-

Compartmentalization of immune responses

Manu Shankar�Hari (Edinburgh, United Kingdom)
-

Sustained inflammation can be associated with mortality

Lieuwe Bos (Amsterdam, Netherlands)
-

Disease tolerance as an important concept

Sebastian Weis (Jena, Germany)
-

Treating fever? � or normothermia?

Mervyn Singer (London, United Kingdom)
-

Discussion

A simple guide to... 100 Hall Afternoon (CET)

INTOXICATIONS

-

Intoxications

Heatherlee Bailey (Durham, United States)

Standard presentation 400 Hall Morning (CET)

RENAL DYSFUNCTION

Moderator(s): Achim J�rres (Cologne, Germany)
Dmytro Khadzhynov (Berlin, Germany)

-

Measure creatinine more frequently

Rinaldo Bellomo (Melbourne, Australia)
-

Kidney responses to novel therapeutic strategies

Can Ince (Rotterdam, Netherlands)
-

Role of identifying subphenotypes

Marlies Ostermann (London, United Kingdom)
-

Management in patients with cirrhosis

Thierry Gustot (Brussels, Belgium)
-

Discussion
-

The optimal blood pressure for the kidneys

Frank van Haren (Sidney, Australia)
-

The best vasopressor for the kidney?

Jacques Duranteau (Le Kremlin-Bic�tre, France)
-

Vasopressin could have renal protective effects

Patrick Honor� (Yvoir, Belgium)
-

Bicarbonate administration: good or bad?

Lui Forni (Guildford, United Kingdom)
-

Discussion

Tutorial 400 Hall Morning (CET)

VENTILATOR DYSSYNCHRONY

-

Ventilator dyssynchrony

Elias N Baedorf Kassis (Boston, United States)

Tutorial 400 Hall Morning (CET)

DRUG TOXICITY IN CANCER PATIENTS

-

Drug toxicity in cancer patients

Stephen M Pastores (New York, United States)

Tutorial 400 Hall Morning (CET)

ACUTE EXACERBATION OF CHRONIC RESPIRATORY DISEASE

-

Acute exacerbation of chronic respiratory disease

Tobias Welte (Hannover, Germany)

Standard presentation 400 Hall Afternoon (CET)

ECCO2R

Moderator(s): Luigi Camporota (London, United Kingdom)
Daniel Talmor (Boston, United States)

-

Physiological principles

Matthias Hilty (Zurich, Switzerland)
-

Selecting the right patients

Ewan Goligher (Toronto, Canada)
-

For moderate to severe ARDS

Alain Combes (Paris, France)
-

Combination with CRRT in ARDS

V Marco Ranieri (Bologna, Italy)
-

Is ECCO2R also good for oxygenation?

Luciano Gattinoni (G�ttingen, Germany)
-

Discussion
-

Break

Standard presentation 400 Hall Afternoon (CET)

HEMATOLOGICAL ISSUES

Moderator(s): Andr� Denault (Montreal, Canada)
Hannah Wunsch (Toronto, Canada)

-

Thrombocytopenia in the ICU

Elie Azoulay (Paris, France)
-

When to suspect a thrombotic microangiopathy

Achim J�rres (Cologne, Germany)
-

Emerging treatment options

Sascha David (Zurich, Switzerland)
-

Discussion
-

Liver-induced coagulopathies

Julia Wendon (London, United Kingdom)
-

Sepsis-induced coagulopathy

Julie Helms (Strasbourg, France)
-

Should we give iron to the critically ill?

Nicole Juffermans (Amsterdam, Netherlands)
-

A research agenda for hemoncology patients

Elie Azoulay (Paris, France)
-

Discussion

Standard presentation Panoramic Room Morning (CET)

ARTIFICIAL INTELLIGENCE IN THE ICU

Moderator(s): Liesbet De Bus (Ghent, Belgium)
Marek Mirski (Baltimore, United States)

-

The future is bright

Vincent Liu (Oakland, United States)
-

� but artificial intelligence has a dark side

Jan De Waele (Ghent, Belgium)
-

� and it�s not smart if it doesn�t improve outcomes

Michelle N Gong (New York, United States)
-

Discussion
-

Machine learning can identify subphenotypes

Edward Schenck (New York, United States)
-

How AI can prevent hemodynamic crises

Alexander Vlaar (Amsterdam, Netherlands)
-

How it may improve hemodynamic management

Michael R Pinsky (Pittsburgh, United States)
-

Discussion
-

How it can analyze microcirculatory alterations

Matthias Hilty (Zurich, Switzerland)
-

How it may predict cerebral complications

Soojin Park (New York, United States)
-

How it may predict coma recovery

Mauro Oddo (Lausanne, Switzerland)
-

Developing further prediction models

Vincent Liu (Oakland, United States)
-

Discussion

Tutorial Panoramic Room Morning (CET)

COAGULOPATHIES (Tuto)

-

Coagulopathies

Julie Helms (Strasbourg, France)

Standard presentation Panoramic Room Afternoon (CET)

WEANING FROM MECHANICAL VENTILATION

Moderator(s): Jan Belohlavek (Prague, Czech Republic)
Armand Mekontso Dessap (Cr�teil, France)

-

What is complicated weaning?

Lise Piquilloud (Lausanne, Switzerland)
-

How to assess muscle strength

Alexandre Demoule (Paris, France)
-

When, where and how to extubate?

Audrey De Jong (Montpellier, France)
-

Discussion
-

Non-traditional risk factors for failed extubation

Hayley B Gershengorn (Miami, United States)
-

How to optimize weaning in children

Adrienne Randolph (Boston, United States)
-

Extubation failure in neurological patient

Chiara Robba (Genoa, Italy)
-

Non-invasive ventilation to support the weaning�process

Gavin Perkins (Warwick, United Kingdom)
-

Discussion

A simple guide to... Panoramic Room Afternoon (CET)

ECMO: THINGS TO REMEMBER

-

ECMO: things to remember

Leen Vercaemst (Leuven, Belgium)

Standard presentation Lippens Room Morning (CET)

IMPROVING VASOPRESSOR USE

Moderator(s): Lewis J Kaplan (Philadelphia, United States)
Xavier Monnet (Le Kremlin-Bic�tre, France)

-

When is the radial artery pressure unreliable?

Andr� Denault (Montreal, Canada)
-

The peripheral i.v. route is acceptable

Hallie Prescott (Ann Arbor, United States)
-

Norepinephrine infusion should be started early

Jean-Louis Teboul (Le Kremlin-Bic�tre, France)
-

How to promote veno-constriction

Daniel De Backer (Braine l�Alleud, Belgium)
-

Discussion
-

Starting with vasopressin?

Diamanto Aretha (Patras, Greece)
-

New vasopressors, new evidence

Ashish K Khanna (Winston-Salem, United States)
-

Angiotensin II has additional properties

Rinaldo Bellomo (Melbourne, Australia)
-

Discussion
-

The vasopressor test

Jan Bakker (New York, United States)
-

Combination therapies in septic shock: when and how?

Sharon Einav (Jerusalem, Israel)
-

When to add an inotropic agent?

Michelle Chew (Link�ping, Sweden)
-

Discussion
-

� or a beta blocker?

Vasileios Papaioannou (Alexandroupolis, Greece)
-

Continuing controversies

Hannah Wunsch (Toronto, Canada)
-

What do we mean by �refractory` septic shock?

Ricard Ferrer (Barcelona, Spain)
-

Discussion

Tutorial Lippens Room Afternoon (CET)

CARDIAC ARREST GUIDELINES

-

Cardiac arrest guidelines

Gavin Perkins (Warwick, United Kingdom)

Standard presentation Lippens Room Afternoon (CET)

RENAL REPLACEMENT THERAPY

Moderator(s): Javier Fernandez (Barcelona, Spain)
Steffen R. Mitzner (Rostock, Germany)

-

Diffusion, convection, adsorption: what�s best?

Claudio Ronco (Vicenza, Italy)
-

Can we predict who will need RRT?

Lui Forni (Guildford, United Kingdom)
-

How the choice may influence recovery

Rinaldo Bellomo (Melbourne, Australia)
-

Discussion
-

CVVHD is so much better than CVVH

Xose L P�rez Fern�ndez (Bueu, Spain)
-

How to effectively prolong CRRT filter life

Tomoko Fujii (Tokyo, Japan)
-

Regional citrate anticoagulation

Joop Jonckheer (Brussels, Belgium)
-

How to reduce the risk of RRT-induced kidney injury

St�phane Gaudry (Bobigny, France)
-

Discussion
-

Optimal fluid management

Marlies Ostermann (London, United Kingdom)
-

Optimal feeding

Joop Jonckheer (Brussels, Belgium)
-

When to stop

Achim J�rres (Cologne, Germany)
-

The remaining questions

Dmytro Khadzhynov (Berlin, Germany)
-

Discussion

Tutorial The Arc Room Morning (CET)

NEW ANTIBIOTICS

-

New antibiotics

Tobias Welte (Hannover, Germany)

Tutorial The Arc Room Morning (CET)

HOW TO TALK TO THE MEDIA ABOUT SCIENTIFIC FINDINGS

-

How to talk to the media about scientific findings

Craig M Coopersmith (Atlanta, United States)

Round table The Arc Room Morning (CET)

ANTIMICROBIAL STEWARDSHIP

Moderator(s): Maya Hites (Brussels, Belgium)

-

Antimicrobial stewardship

            Paul Dark (Manchester, United Kingdom)

            Jan De Waele (Ghent, Belgium)

            Lennie Derde (Utrecht, Netherlands)

            Jos�-Artur Paiva (Porto, Portugal)

Tutorial The Arc Room Morning (CET)

MACROPHAGE ACTIVATION SYNDROME

-

Macrophage activation syndrome

Evangelos Giamarellos�Bourboulis (Athens, Greece)

Round table The Arc Room Morning (CET)

ECPR WHEN, WHERE, HOW AND FOR WHOM?

Moderator(s): Fabio S Taccone (Brussels, Belgium)

-

ECPR: when, where, how and for whom?

            Jan Belohlavek (Prague, Czech Republic)

            Daniel De Backer (Braine l�Alleud, Belgium)

            Claudio Sandroni (Rome, Italy)

            Leen Vercaemst (Leuven, Belgium)

Round table The Arc Room Afternoon (CET)

HOW TO COPE WITH ICU BURNOUT?

Moderator(s): Michelle Chew (Link�ping, Sweden)

-

How to cope with ICU burnout?

            Daniel Brodie (Baltimore, United States)

            Sheila N Myatra (Mumbai, India)

            Stephen M Pastores (New York, United States)

            Fabio S Taccone (Brussels, Belgium)

Tutorial The Arc Room Afternoon (CET)

DYSPNEA IN MECHANICALLY VENTILATED PATIENTS

-

Dyspnea in mechanically ventilated patients

Alexandre Demoule (Paris, France)

Tutorial The Arc Room Afternoon (CET)

COMA

-

Coma

Raimund Helbok (Linz, Austria)

Tutorial The Arc Room Afternoon (CET)

HEMODYNAMIC MONITORING TECHNIQUES

-

Hemodynamic monitoring techniques

Xavier Monnet (Le Kremlin-Bic�tre, France)

Tutorial The Arc Room Afternoon (CET)

ADVANCED RESPIRATORY MONITORING

-

Advanced respiratory monitoring

Lise Piquilloud (Lausanne, Switzerland)

Round table The Arc Room Afternoon (CET)

WHAT TEMPERATURE AFTER CARDIAC ARREST?

Moderator(s): Giuseppe Citerio (Monza, Italy)

-

What temperature after cardiac arrest?

            Jerry Nolan (Bath, United Kingdom)

            Chiara Robba (Genoa, Italy)

            Claudio Sandroni (Rome, Italy)

            Markus Skrifvars (Helsinki, Finland)

Case discussion Box 1 Morning (CET)

A CASE OF DIARRHEA

-

A case of diarrhea

Annika Reintam Blaser (Tartu, Estonia)

Meet the experts Box 1 Morning (CET)

ADVANCING SEDATION STRATEGIES

-

Advancing sedation strategies

Michael Reade (Brisbane, Australia)

Yahya Shehabi (Clayton, Australia)

Meet the experts Box 1 Morning (CET)

NON-INVASIVE VENTILATORY SUPPORT

-

Non-invasive ventilatory support

Massimo Antonelli (Rome, Italy)

Lise Piquilloud (Lausanne, Switzerland)

Meet the experts Box 1 Morning (CET)

BLOOD PURIFICATION TECHNIQUES

-

Blood purification techniques

Gabriella Bottari (Rome, Italy)

Claudio Ronco (Vicenza, Italy)

Clinical Challenges Box 1 Morning (CET)

MONITORING RESPIRATORY MECHANICS, DRIVE, AND EFFORT

-

Monitoring respiratory mechanics, drive, and effort

Giacomo Grasselli (Milan, Italy)

Leo Heunks (Rotterdam, Netherlands)

Case discussion Box 1 Morning (CET)

CAR-T TOXICITY

-

CAR-T toxicity

Victoria Metaxa (London, United Kingdom)

Demonstration Box 1 Afternoon (CET)

MANAGEMENT OF THORACIC TRAUMA

-

Management of thoracic trauma

Jacques Duranteau (Le Kremlin-Bic�tre, France)

Marc Maegele (Cologne, Germany)

Clinical Challenges Box 1 Afternoon (CET)

NON-RESOLVING CONFLICTS WITH RELATIVES

-

Non-resolving conflicts with relatives

Elie Azoulay (Paris, France)

Victoria Metaxa (London, United Kingdom)

Clinical Challenges Box 1 Afternoon (CET)

REFEEDING SYNDROME

-

Refeeding syndrome

Annika Reintam Blaser (Tartu, Estonia)

Arthur van Zanten (Ede, Netherlands)

Demonstration Box 1 Afternoon (CET)

TRANSESOPHAGEAL LUNG ULTRASONOGRAPHY

-

Transesophageal lung ultrasonography

Daniel De Backer (Braine l�Alleud, Belgium)

Paul H Mayo (New York, United States)

Demonstration Box 1 Afternoon (CET)

LUNG RECRUITMENT

-

Lung recruitment

Laurent Brochard (Toronto, Canada)

John J Marini (St Paul, United States)

Demonstration Box 2 Morning (CET)

COAGULOPATHY: DIFFERENTIAL DIAGNOSIS

-

Coagulopathy: differential diagnosis

Elie Azoulay (Paris, France)

Clinical Challenges Box 2 Morning (CET)

ANTIBIOTIC PROPHYLAXIS IN PATIENTS COLONIZED WITH MDR BACTERIA

-

Antibiotic prophylaxis in patients colonized with MDR bacteria

Philippe Montravers (Paris, France)

Pedro Povoa (Lisbon, Portugal)

Clinical Challenges Box 2 Morning (CET)

MASSIVE BLEEDING [CC]

-

Massive bleeding

Nicole Juffermans (Amsterdam, Netherlands)

Marc Maegele (Cologne, Germany)

Demonstration Box 2 Morning (CET)

CRITICAL CARE ECHOCARDIOGRAPHY

-

Critical care echocardiography

Anthony McLean (Sydney, Australia)

Susanna Price (London, United Kingdom)

Demonstration Box 2 Morning (CET)

VASOPRESSOR MANAGEMENT IN SEPTIC SHOCK

-

Vasopressor management in septic shock

Arthur van Zanten (Ede, Netherlands)

Demonstration Box 2 Morning (CET)

ADVANCED HEMODYNAMIC MONITORING IN THE ICU

-

Advanced hemodynamic monitoring in the ICU

Alexander Vlaar (Amsterdam, Netherlands)

Demonstration Box 2 Afternoon (CET)

HOW TO USE TTM AFTER CARDIAC ARREST?

-

How to use TTM after cardiac arrest?

Rinaldo Bellomo (Melbourne, Australia)

Jerry Nolan (Bath, United Kingdom)

Clinical Challenges Box 2 Afternoon (CET)

ARE YOU AWAKE? ARE YOU CONSCIOUS?

-

Are you awake? Are you conscious?

Jan Claassen (New York, United States)

Jacques Duranteau (Le Kremlin-Bic�tre, France)

Clinical Challenges Box 2 Afternoon (CET)

ANALGESIA AND SEDATION STRATEGIES FOR NEUROLOGICAL PATIENTS

-

Analgesia and sedation strategies for neurological patients

Pierre Bouzat (Grenoble, France)

Marek Mirski (Baltimore, United States)

Clinical Challenges Box 2 Afternoon (CET)

THE PATIENT WHO BLEEDS BUT NEEDS ANTICOAGULANTS

-

The patient who bleeds but needs anticoagulants

Julie Helms (Strasbourg, France)

Beverley Hunt (London, United Kingdom)

Clinical Challenges Box 2 Afternoon (CET)

INTERSTITIAL LUNG DISEASES

-

Interstitial lung diseases

Angelique de Man (Amsterdam, Netherlands)

Janet Diaz (Geneva, Switzerland)

Thursday 23 March 2023

Standard presentation Gold Hall Morning (CET)

PANDEMICS: THE BIG PICTURE

Moderator(s): Tomoko Fujii (Tokyo, Japan)
Yahya Shehabi (Clayton, Australia)

-

From polio to COVID-19

Hannah Wunsch (Toronto, Canada)
-

What infectious diseases�are emerging?

Janet Diaz (Geneva, Switzerland)
-

How research reshaped practice

Djillali Annane (Garches, France)
-

Discussion
-

There is a need for �frugal innovation`

Armand Mekontso Dessap (Cr�teil, France)
-

How social media broke science

Gordon Rubenfeld (Toronto, Canada)
-

Anticipating the next pandemic: resilience is the key

Lennie Derde (Utrecht, Netherlands)
-

Discussion
-

POSTER AWARDS

Interactive program

Tuesday 21 March 2023

Welcome

Report of the Round Table conference: ICU populations: from syndromes to phenotypes

Heterogeneous treatment effects of therapeutic-dose heparin in patients hospitalized for COVID-19

Intravenous ravulizumab in mechanically ventilated patients hospitalized with severe COVID-19

Hydrocortisone in severe community-acquired pneumonia

Early administration of prothrombin complex concentrate in trauma patients at risk of massive transfusion (PROCOAG)

Tight glucose control in the absence of early parenteral nutrition

Low versus standard calorie and protein feeding in ventilated adults with shock (NUTRIREA-3)

Max Harry Weil lecture: equity and equality in the ICU

Hospital violence: critical care professionals at risk

How to make it possible?

How ECMO can facilitate it

How we do it

How we can improve it

Discussion

Immune profiling could identify severity

A better understanding of immunomodulation

The different responses to convalescent plasma therapy

Discussion

It was different in children?

About the heterogeneity of myocarditis

How the epidemiology of bacterial infections has been affected

Discussion

About antivirals

About other ICU treatments

Anti-C5a antibody was the best

Inhaled heparin as an option

Discussion

About stress, anxiety and burnout among the health care team

About living guidelines

Is there still something to learn?

Discussion

Critical care management

A role for other medical therapies?

Can ROTEM help to predict cerebral ischemia?

Delayed cerebral ischemia: still a role for induced hypertension?

Discussion

Catheter-associated bloodstream infections

Probiotics may decrease the risk of lung infection

Advanced airway devices to reduce risk of VAP

Other new approaches to VAP prevention

Discussion

SDD - here we go again?

Why aren�t you using SDD?

Indications for antibiotic prophylaxis

Discussion

Break

A very heterogeneous entity!

Different in pregnant patients?

How has outcome improved?

Extreme therapies

Discussion

Current indications for ICP monitoring

Benefits and risks of hyperosmolar therapy

Is hypertonic lactate the solution?

Is hypertonic saline the solution?

Discussion

Pupil reactivity: the simplest method

Biomarkers

Brain tissue oxygenation

Discussion

Brain metabolic monitoring

Multimodal brain monitoring: EEG + Doppler + NIRS

How I integrate it all

It�s not only a matter of thresholds

Discussion

Clinical trials in COVID:

Quality of life after cardiac arrest

Frailty and persistent critical illness

Altered DNA methylation drives PICS

What happens to the cirrhotic patient?

Discussion

ARDS in immunocompromised patients is a specific entity

Pediatric ARDS is also different

Respiratory subsets: my personal view

Discussion

ARDS subphenotypes: lessons from COVID-19

Phenotypes are moving closer to clinical trials